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Wed, Mar 11

Targetmol added a comment to F689337: workcard-thumbgrid-profile.

https://www.targetmol.com/compound/nocodazole
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.

Wed, Mar 11, 6:25 AM
Targetmol added a comment to F689339: pinboard-thumbgrid-profile.

https://www.targetmol.com/compound/selinexor%20%ef%bc%88kpt-330%ef%bc%89
Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.

Wed, Mar 11, 6:18 AM
Targetmol added a comment to F689323: preview-preview-profile.

LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).
https://www.targetmol.com/compound/ldn193189

Wed, Mar 11, 6:15 AM
Targetmol added a comment to F689336: thumbgrid-profile.

RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.
https://www.targetmol.com/compound/repsox

Wed, Mar 11, 6:11 AM
Targetmol added a comment to F689334: thumbgrid-pinboard-profile.

MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.
https://www.targetmol.com/compound/mg-132

Wed, Mar 11, 6:10 AM