Biofilm is a highly organized group with structure, coordination and function. The biological characteristics of biofilm bacteria are significantly different from planktonic bacteria. They have stronger environmental adaptability and can resist the action of phagocytes, evade host immunity, especially drug resistance. To further explore the genetic material basis and maintenance mechanism of bacterial biofilm formation, physiological and biochemical characteristics and its regulatory mechanism, biofilm bacteria depolymerization and recolonization mechanism, the relationship between biofilm and the body's immunity, biofilm drug resistance mechanism and a series of issues have a great impact on enriching people's control the means of bacterial infection are of great clinical significance. Learn more: biofilm classification